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Center for Applied Biotechnology and Molecular Medicine

Publications 2024

* supported by a CABMM Start-up Grant
** performed partly on the CABMM Research Platform

Bteich Y, Assaf JF, Müller F, Gendy JE, Jacob S, Hafezi F, Awwad ST
Femtosecond Laser-Assisted Graft Preparation and Implantation of Corneal Allogeneic Intrastromal Ring Segments for Corneal Ectasia: 1-Year Results
Cornea. 2024 Oct 29 [Epub ahead of print]
PubMed

Fontes BM, Nosé RM, Hafezi F, Torres-Netto EA
CTK-like syndrome: Corneal opacity and flattening following sequential intracorneal ring implantation and corneal cross-linking
Am J Ophthalmol Case Rep. 2024 Oct 25;36:102196
PubMed

Zillinger LS, Liesegang A, Hustedt K, Schnepel N, Sauerwein H, Schmicke M, Schwennen C, Muscher-Banse AS
Influence of N- and/or P-restriction on bone metabolism in young goats
Br J Nutr. 2024 Oct 15;1-13 [Epub ahead of print]
PubMed

Karami P, Martin R, Laurent A, Nam HY, Philippe V, Applegate LA, Pioletti DP
An Adhesive Hydrogel Technology for Enhanced Cartilage Repair: A Preliminary Proof of Concept
Gels. 2024 Oct 14;10(10):657
PubMed

Raimondi F, Siow KM, Wrona D, Fuster-García C, Pastukhov O, Schmitz M, Bargsten K, Kissling L, Swarts DC, Andrieux G, Cathomen T, Modlich U, Jinek M, Siler U, Reichenbach J
Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements
Commun Biol. 2024 Oct 9;7(1):1291
PubMed

** Kollros L, Torres-Netto EA, Lu NJ, Hillen M, Hafezi F
Visual rehabilitation with mini scleral contact lenses in scarred corneas
J Fr Ophtalmol. 2024 Oct;47(8):104235
PubMed

Flahaut M, Laurent A, Fuenteslópez CV, Cui Z, Ye H, Scaletta C, Hirt-Burri N, Applegate LA, Patrulea V
Reassessing Long-Term Cryopreservation Strategies for Improved Quality, Safety, and Clinical Use of Allogeneic Dermal Progenitor Cells
J Invest Dermatol. 2024 Oct;144(10):2125-2135
PubMed

Jeannerat A, Peneveyre C, Jaccoud S, Philippe V, Scaletta C, Hirt-Burri N, Abdel-Sayed P, Martin R, Applegate LA, Pioletti DP, Laurent A
Banked Primary Progenitor Cells for Allogeneic Intervertebral Disc (IVD) Therapy: Preclinical Qualification and Functional Optimization within a Cell Spheroid Formulation Process
Pharmaceutics. 2024 Sep 29;16(10):1274
PubMed

Karami P, Laurent A, Philippe V, Applegate LA, Pioletti DP, Martin R
Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels
Int J Mol Sci. 2024 Sep 16;25(18):9984
PubMed

Mangiavacchi A, Morelli G, Reppe S, Saera-Vila A, Liu P, Eggerschwiler B, Zhang H, Bensaddek D, Casanova EA, Medina Gomez C, Prijatelj V, Della Valle F, Atinbayeva N, Izpisua Belmonte JC, Rivadeneira F, Cinelli P, Gautvik KM, Orlando V
LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response
EMBO J. 2024 Sep;43(17):3587-3603
PubMed

Awwad ST, Bteich Y, Assaf JF, Ghosn A, Hafezi F, Torres-Netto E, Chacra LM, Kozhaya K
Prospective Objective Analysis of Corneal Haze Following Customized Transepithelial PRK Without Mitomycin C Combined With Accelerated Corneal Cross-Linking Versus Corneal Cross-Linking Alone
J Refract Surg. 2024 Sep;40(9):e583-e594
PubMed

Kling S, Frigelli M, Aydemir ME, Tahsini V, Torres-Netto EA, Kollros L, Hafezi F
Optical coherence tomography quantifies gradient refractive index and mechanical stiffness gradient across the human lens
Commun Med (Lond). 2024 Aug 12;4(1):162
PubMed

Franco-Obregón A, Tai YK
Are Aminoglycoside Antibiotics TRPing Your Metabolic Switches?
Cells. 2024 Jul 29;13(15):1273
PubMed

Ariyanfar A, Klein K, von Rechenberg B, Darwiche S, Dailey HL
Adaptive Image Segmentation Reveals Substantial Cortical Bone Remodeling During Early Fracture Repair
Comput Methods Biomech Biomed Eng Imaging Vis. 2024;12(1):2345165 [Epub ahead of print]
PubMed

Weber P, Asadikorayem M, Zenobi-Wong M
Zwitterionic Poly-Carboxybetaine Polymers Restore Lubrication of Inflamed Articular Cartilage
Adv Healthc Mater. 2024 Jul 15;e2401623
PubMed

** Hafezi NL, Aydemir ME, Lu NJ, Torres-Netto EA, Hillen M, Koppen C
The Resistance of Riboflavin/UV-A Corneal Cross-Linking to Enzymatic Digestion Is Oxygen-Independent
Cornea. 2024 Jul 1;43(7):895-898
PubMed

von Doernberg MC, von Rechenberg B, Richter H
Retrospective evaluation of radiofrequency volumetric tissue reduction for hypertrophic turbinates in dogs with brachycephalic obstructive airway syndrome
PLoS One. 2024 Jul 1;19(7):e0306391
PubMed

Guerrero J, Maevskaia E, Ghayor C, Bhattacharya I, Weber FE
Optimizing Filament-Based TCP Scaffold Design for Osteoconduction and Bone Augmentation: Insights from In Vivo Rabbit Models
J Funct Biomater. 2024 Jun 25;15(7):174
PubMed

Schleich S, Kronen P, Krivitsky A, Paunović N, Brian CF, Karol AA, Geks A, Bao Y, Leroux JC, von Rechenberg B, Franzen D, Klein K
Effects of shape and structure of a new 3D-printed personalized bioresorbable tracheal stent on fit and biocompatibility in a rabbit model
PLoS One. 2024 Jun 25;19(6):e0300847
PubMed

Iversen JN, Fröhlich J, Tai YK, Franco-Obregón F
Synergistic Cellular Responses Conferred by Concurrent Optical and Magnetic Stimulation Are Attenuated by Simultaneous Exposure to Streptomycin: An Antibiotic Dilemma
Bioengineering (Basel). 2024 Jun 21;11(7):637
PubMed

Maevskaia E, Ghayor C, Bhattacharya I, Guerrero J, Weber FE
TPMS Microarchitectures for Vertical Bone Augmentation and Osteoconduction: An In Vivo Study
Materials (Basel). 2024 May 24;17(11):2533
PubMed

Siow KM, Güngör M, Wrona D, Raimondi F, Pastukhov O, Tsapogas P, Menzi T, Schmitz M, Kulcsár PI, Schwank G, Schulz A, Jinek M, Modlich U, Siler U, Reichenbach J
Targeted knock-in of NCF1 cDNA into the NCF2 locus leads to myeloid phenotypic correction of p47 phox -deficient chronic granulomatous disease.
Mol Ther Nucleic Acids. 2024 May 24;35(3):102229
PubMed

Porcello A, Chemali M, Marques C, Scaletta C, Lourenço K, Abdel-Sayed P, Raffoul W, Hirt-Burri N, Applegate LA, Laurent A
Dual Functionalization of Hyaluronan Dermal Fillers with Vitamin B3: Efficient Combination of Bio-Stimulation Properties with Hydrogel System Resilience Enhancement
Gels. 2024 May 24;10(6):361
PubMed

Kessler F, Arnke K, Eggerschwiler B, Neldner Y, Märsmann S, Gröninger O, Casanova EA, Weber FA, König MA, Stark WJ, Pape HC, Cinelli P, Tiziani S
Murine iPSC-Loaded Scaffold Grafts Improve Bone Regeneration in Critical-Size Bone Defects
Int J Mol Sci. 2024 May 20;25(10):5555
PubMed

Zscherpe P, Kalbitz J, Weber LA, Paschke R, Mäder K, von Rechenberg B, Cavalleri JV, Meißner J, Klein K
Potent drug delivery enhancement of betulinic acid and NVX-207 into equine skin in vitro - a comparison between a novel oxygen flow-assisted transdermal application device and microemulsion gels
BMC Vet Res. 2024 May 16;20(1):202
PubMed

Thomson BR, Schwendinger N, Beckmann K, Gentinetta T, Couto D, Wymann S, Verdon V, Buzzi RM, Akeret K, Kronen PW, Weinberger EM, Held U, Seehusen F, Richter H, Schaer DJ, Hugelshofer M
Haptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in Sheep
Transl Stroke Res. 2024 Apr 23 [Epub ahead of print]
PubMed

Micheels P, Porcello A, Bezzola T, Perrenoud D, Christen MO, Applegate LA, Laurent A
Comprehensive Evaluation of Injectability Attributes in OxiFree™ Dermal Fillers: MaiLi® Product Variants and Clinical Case Reports
Gels. 2024 Apr 19;10(4):276
PubMed

von Rechenberg B, Gehrke RS, Klein K, Kronen P, Darwiche S, Zbinden J, Wieser K, Lädermann A
Studying Edema Formation After Release of the Infraspinatus Muscle as an Experimental Model of Rotator Cuff Lesions in Sheep: A Histological Analysis
Am J Sports Med. 2024 Apr;52(5):1319-1327
PubMed

Marques C, Hadjab F, Porcello A, Lourenço K, Scaletta C, Abdel-Sayed P, Hirt-Burri N, Applegate LA, Laurent A
Mechanistic Insights into the Multiple Functions of Nicotinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products
Antioxidants (Basel). 2024 Mar 30;13(4):425
PubMed

Maevskaia E, Guerrero J, Ghayor C, Bhattacharya I, Weber FE
Functionalization of Ceramic Scaffolds with Exosomes from Bone Marrow Mesenchymal Stromal Cells for Bone Tissue Engineering
Int J Mol Sci. 2024 Mar 29;25(7):3826
PubMed

Olthof MGL, Hasler A, Valdivieso P, Flück M, Gerber C, Gehrke R, Klein K, von Rechenberg B, Snedeker JG, Wieser K
Poly(ADP-Ribose) Polymerase-Inhibitor Talazoparib Inhibits Muscle Atrophy and Fatty Infiltration in a Tendon Release Infraspinatus Sheep Model: A Pilot Study
Metabolites. 2024 Mar 26;14(4):187
PubMed

Ren T, Inglis B, Darwiche S, Dailey HL
Torsion constants and virtual mechanical tests are valid image-based surrogate measures of ovine fracture healing
J Orthop Res. 2024 Mar 16 [Epub ahead of print]
PubMed

Tai YK, Iversen JN, Chan KKW, Fong CHH, Abdul Razar RB, Ramanan S, Yap LYJ, Yin JN, Toh SJ, Wong CJK, Koh PFA, Huang RYJ, Franco-Obregón A
Secretome from Magnetically Stimulated Muscle Exhibits Anticancer Potency: Novel Preconditioning Methodology Highlighting HTRA1 Action
Cells. 2024 Mar 5;13(5):460
PubMed

Labouchère A, Haselbach D, Michetti M, Pythoud C, Raffoul W, Applegate LA, Hirt-burri N, de Buys Roessingh A
A New Ex Vivo Human Skin Burn Model
J Burn Care Res. 2024 Mar 4;45(2):308-317
PubMed

** Chacra LM, Helwe C, Assaf JF, Yehia M, Baroud S, Torres-Netto EA, Hafezi F, Awwad ST
Accelerated Corneal Cross-linking with 20`-soaking HPMC/riboflavin versus Conventional Cross-linking with 30`-soaking Dextran/riboflavin
J Cataract Refract Surg. 2024 Mar 1;50(3):236-243
PubMed

** Aydemir ME, Hafezi NL, Lu NJ, Torres-Netto EA, Hillen M, Koppen C, Hafezi F
Combining Riboflavin/UV-A Light and Rose Bengal/Green Light Corneal Cross-Linking Increases the Resistance of Corneal Enzymatic Digestion
Transl Vis Sci Technol. 2024 Jan 2;13(1):30
PubMed